Structure of PDB 8cbu Chain B

Receptor sequence
>8cbuB (length=139) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence]
SPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAG
RWPVKTVHTDNGSNFTSTTVKAACWWAGIKQEFGVIESMNKELKKIIGQV
RDQAEHLKTAVQMAVFIHNKKRKGYSAGERIVDIIATDI
3D structure
PDB8cbu Biological and Structural Analyses of New Potent Allosteric Inhibitors of HIV-1 Integrase.
ChainB
Resolution2.44 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 U60 B A169 E170 H171 T174 M178 A104 E105 H106 T109 M113
BS02 MG B D64 D116 D8 D60
BS03 U60 B Q95 T124 T125 A128 A129 W132 Q39 T68 T69 A72 A73 W76
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
Biological Process
GO:0015074 DNA integration

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Molecular Function
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Biological Process
External links
PDB RCSB:8cbu, PDBe:8cbu, PDBj:8cbu
PDBsum8cbu
PubMed37310224
UniProtP12497|POL_HV1N5 Gag-Pol polyprotein (Gene Name=gag-pol)

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