Structure of PDB 8cbh Chain B

Receptor sequence
>8cbhB (length=486) Species: 9606 (Homo sapiens) [Search protein sequence]
RRWFHPNITGVEAENLLLTRGVDGSFLARPSNPGDFTLSVRRNGAVTHIK
IQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKVIELKYPLNCADPTSE
RWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDSKVTH
VMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTT
RINAAEIESRVRELSKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNR
YKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEKKSYIATQGCLQNTV
NDFWRMVFQENSRVIVMTTKEVEGKSKCVKYWPDEYALKEYGVMRVRNVK
ESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFL
EEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDID
VPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETL
3D structure
PDB8cbh Discovery of a Novel Series of Imidazopyrazine Derivatives as Potent SHP2 Allosteric Inhibitors.
ChainB
Resolution2.24 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 U70 B T108 R111 F113 H114 T219 E249 E250 T253 L254 P491 Q495 T98 R101 F103 H104 T200 E221 E222 T225 L226 P452 Q456
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8cbh, PDBe:8cbh, PDBj:8cbh
PDBsum8cbh
PubMed36793438
UniProtQ06124|PTN11_HUMAN Tyrosine-protein phosphatase non-receptor type 11 (Gene Name=PTPN11)

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