Structure of PDB 8c7x Chain B

Receptor sequence
>8c7xB (length=262) Species: 9606 (Homo sapiens) [Search protein sequence]
DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQA
FKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHASETK
FEMKKLIDIARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGL
ATVSGSILWMAPEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNIN
NRDQIIEMVGRGSLSPDLSKVRSNCPKRMKRLMAECLKKKRDERPSFPRI
LAEIEELARELS
3D structure
PDB8c7x Design, synthesis and characterisation of a novel type II B-RAF paradox breaker inhibitor.
ChainB
Resolution1.65 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TXV B A481 K483 E501 L505 L514 T529 Q530 W531 C532 H574 I592 G593 D594 F595 A34 K36 E54 L58 L67 T82 Q83 W84 C85 H127 I145 G146 D147 F148
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8c7x, PDBe:8c7x, PDBj:8c7x
PDBsum8c7x
PubMed36878151
UniProtP15056|BRAF_HUMAN Serine/threonine-protein kinase B-raf (Gene Name=BRAF)

[Back to BioLiP]