Structure of PDB 8c53 Chain B

Receptor sequence

>8c53B (length=447) Species: 5691 (Trypanosoma brucei)

NTNLRTKTLRDGTTAEELFSQDGLSFNDFIILPGFIDFDSSKVNVSGQFT
KNILLHLPLVSSPMDTVTESSMARAMALMGGIGVIHNNCTVEQQARMVRS
VKLYRNGFIMKPKSVSPDVPVSTIRNIKSEKGISGILVTEGGKYDGKLLG
IVCTKDIDFVKDASAPVSQYMTRRENMTVERYPIKLEEAMDVLNRSRHGY
LPVLNDKDEVVCLCSRRDAVRARDYPNSSLDRNGHLLCAAATSTREADKG
RVAALSEAGIDVLVLDSSQGNTIYQVSFIRWVKKTYPHLEVVAGNVVTQD
QAKNLIDAGADSLRIGMGVLACGRPQATAIYKVARYAASRGVPCVADGGL
RNVGDVCKALAVGANVAMLGSMIAGTSETPGEYFFKDGMRLKGAVLDKGS
VLKLLAYIHKGLQQSAQDIGEVSFDAIREKVYEGQVLFNRRSLTAQS

3D structure

• PDB: 8c53 InCellCryst - A streamlined approach to structure elucidation using in cellulo crystallized recombinant proteins
• Chain: B
• Resolution: 2.3 Å

Enzymatic activity

• Enzyme Commision number: 1.1.1.205: IMP dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ATP	B	K157 R199	K155 R197
BS02	GDP	B	L105 I111 K113 K115 K133 G137 L215	L103 I109 K111 K113 K131 G135 L213
BS03	ATP	B	C155 D158 T174 M179 T180 H200 G201 Y202	C153 D156 T172 M177 T178 H198 G199 Y200

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0003824 catalytic activity
• GO:0003938 IMP dehydrogenase activity
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006164 purine nucleotide biosynthetic process
• GO:0006177 GMP biosynthetic process
• GO:0006183 GTP biosynthetic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0020015 glycosome

External links

• PDB: RCSB:8c53, PDBe:8c53, PDBj:8c53
• PDBsum: 8c53
• PubMed: 38402242
• UniProt: P50098|IMDH_TRYBB Inosine-5'-monophosphate dehydrogenase