Structure of PDB 8c41 Chain B

Receptor sequence

>8c41B (length=720) Species: 1313 (Streptococcus pneumoniae) [Search protein sequence]

KLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAK
AKMADILKNEEINTMIYTIGAGVGADFSIEDANYDKIIIMTDADTDGAHI
QTLLLTFFYRYMRPLVEAGHVYIALPPLYKMSKGKGKKEEVAYAWTDGEL
EELRKQFGKGATLQRYKGLGEMNADQLWETTMNPETRTLIRVTIEDLARA
ERRVNVLMGDKVEPRRKWIEDNVKFTLEEATVFHMSNIQNMSLEDIMGER
FGRYSKYIIQDRALPDIRDGLKPVQRRILYSMNKDSNTFDKSYRKSAKSV
GNIMGNFHPHGDSSIYDAMVRMSQNWKNREILVEMHGNNGSMDGDPPAAM
RYTEARLSEIAGYLLQDIEKKTVPFAWNFDDTEKEPTVLPAAFPNLLVNG
STGISAGYATDIPPHNLAEVIDAAVYMIDHPTAKIDKLMEFLPGPDFPTG
AIIQGRDEIKKAYETGKGRVVVRSKTEIEKLKGGKEQIVITEIPYEINKA
NLVKKIDDVRVNNKVAGIAEVRDESDRDGLRIAIELKKDANTELVLNYLF
KYTDLQINYNFNMVAIDNFTPRQVGIVPILSSYIAHRREVILARSRFDKE
KAEKRLHIVEGLIRVISILDEVIALIRASENKADAKENLKVSYDFTEEQA
EAIVTLQLYRLTNTDVVVLQEEEAELREKIAMLAAIIGDERTMYNLMKKE
LREVKKKFATPRLSSLEDTA

3D structure

PDB

8c41 The nature of the molecular interactions at high resolution of the Streptococcus pneumoniae topoisomerase IV-DNA complex with the novel fluoroquinolone Delafloxacin.

Chain

Resolution

2.393 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	B	E433 D510 R1028 K1038 V1040 H1074 H1076 S1080 R1087 K1093 T1168 I1170 E1262	E19 D96 R262 K272 V274 H308 H310 S314 R321 K327 T402 I404 E496
BS02	dna	B	K458 I460 N461 K464 H513 V626 R629 Y1118 I1170 S1171 G1173 Y1174 A1175 R1235 N1326	K44 I46 N47 K50 H99 V212 R215 Y352 I404 S405 G407 Y408 A409 R469 N560
BS03	MG	B	F1316 K1317 T1319 Q1322	F550 K551 T553 Q556
BS04	TE9	B	D435 R456 G457 S1079	D21 R42 G43 S313

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524	ATP binding

	Biological Process
GO:0006259	DNA metabolic process
GO:0006265	DNA topological change

	Cellular Component
GO:0005694	chromosome

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8c41, PDBe:8c41, PDBj:8c41
PDBsum	8c41
PubMed
UniProt	P72525\|PARC_STRPN DNA topoisomerase 4 subunit A (Gene Name=parC)

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