Structure of PDB 8c3o Chain B

Receptor sequence
>8c3oB (length=768) Species: 9606 (Homo sapiens) [Search protein sequence]
GSCKGRCELCRCDNLCKSYTSCCHDFDELCLKTARGWECTKDRCGEVRNE
ENACHCSEDCLARGDCCTNYQVVCKGESHWVDDDCEEIKAAECPAGFVRP
PLIIFSVDGFRASYMKKGSKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNL
YTLATGLYPESHGIVGNSMYDPVFDATFHLRGREKFNHRWWGGQPLWITA
TKQGVKAGTFFWSVVIPHERRILTILQWLTLPDHERPSVYAFYSEQPDFS
GHKYGPFGPEMTNPLREIDKIVGQLMDGLKQLKLHRCVNVIFVGDHGMED
VTCDRTEFLSNYLTNVDDITLVPGTLGRIRSKFSNNAKYDPKAIIAALTC
KKPDQHFKPYLKQHLPKRLHYANNRRIEDIHLLVERRWHVARKPLDVYCF
FQGDHGFDNKVNSMQTVFVGYGSTFKYKTKVPPFENIELYNVMCDLLGLK
PAPNNGTHGSLNHLLRTNTFRPTMPEEVTRPNYPGIMYLQSDFDLGCTCD
DERHLLYGRPAVLYRTRYDILYHTDFESGYSEIFLMPLWTSYTVSKQAEV
SSVPDHLTSCVRPDVRVSPSFSQNCLAYKNDKQMSYGFLFPPYLSSSPEA
KYDAFLVTNMVPMYPAFKRVWNYFQRVLVKKYASERNGVNVISGPIFDYD
YDGLHDTEDKIKQYVEGSSIPVPTHYYSIITSCLDFTQPADKCDGPLSVS
SFILPHRPDNEESCNSSEDESKWVEELMKMHTARVRDIEHLTSLDFFRKT
SRSYPEILTLKTYLHTYE
3D structure
PDB8c3o Discovery of potent chromone-based autotaxin inhibitors inspired by cannabinoids.
ChainB
Resolution2.47 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.39: alkylglycerophosphoethanolamine phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5JK B Y83 Y215 W255 I262 F275 Y19 Y151 W191 I198 F211
BS02 T8R B L214 A218 F275 W276 Y307 L150 A154 F211 W212 Y243
BS03 ZN B D312 H316 H475 D248 H252 H405
BS04 ZN B D172 T210 D359 H360 D108 T146 D295 H296
BS05 CA B D765 D767 D769 L771 D773 D648 D650 D652 L654 D656
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0005044 scavenger receptor activity
GO:0016787 hydrolase activity
GO:0030247 polysaccharide binding
GO:0046872 metal ion binding
Biological Process
GO:0006955 immune response

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Molecular Function
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Biological Process
External links
PDB RCSB:8c3o, PDBe:8c3o, PDBj:8c3o
PDBsum8c3o
PubMed37976710
UniProtQ13822|ENPP2_HUMAN Autotaxin (Gene Name=ENPP2)

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