Structure of PDB 8c08 Chain B

Receptor sequence
>8c08B (length=269) Species: 9606 (Homo sapiens) [Search protein sequence]
VFHLIRNEDLIFNESLGQGTFTKIFKGVRRELHETEVLLKVLDKAHRNYS
ESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKN
KNCINILWKLEVAKQLAAAMHFLEENTLIHGNVCAKNILLIREEDRKTGN
PPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGT
TLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLINNCMDYE
PDHRPSFRAIIRDLNSLFT
3D structure
PDB8c08 Erythropoietin signaling is mediated by receptor dimerization through JAK2 pseudokinase domain
ChainB
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP B T555 T557 L579 K581 Q626 F628 V629 G632 S633 N673 K677 N678 L680 T20 T22 L38 K40 Q85 F87 V88 G91 S92 N132 K136 N137 L139
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8c08, PDBe:8c08, PDBj:8c08
PDBsum8c08
PubMed38457493
UniProtO60674|JAK2_HUMAN Tyrosine-protein kinase JAK2 (Gene Name=JAK2)

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