Structure of PDB 8bzx Chain B

Receptor sequence
>8bzxB (length=568) Species: 573 (Klebsiella pneumoniae) [Search protein sequence]
SFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFA
SGLGTVELTVALHYVYNTPFDRLIWDVGHQAYPHKILTGRRDKIGTIRQK
GGLHPFPWRGESEYDVLSVGHSSTSISAGIGVAIAAAKEDKQRRAVCVIG
DGAITAGMAFEAMNHAGDIKPDLLVVLNDNEMSISENVGALNNHGGPGTL
FEELGFNYIGPVDGHDVLGLVSTLKNMRDLKGPQFLHIMTKKGRGYEPAE
KDPITFHAVPKFDHTLPSYSKIFGDWLCETAAKDNKLMAITPAMREGSGM
VEFSKKFPDRYFDVAIAEQHAVTFAAGLAIGDYKPVVAIYSTFLQRAYDQ
VIHDVAIQKLPVLFAIDRAGIVGADGQTHQGAFDLSFLRCIPDMVVMTPS
DENECRQMLYTGYHYSDGPCAVRYPRGSGTGATLEPLASLPIGKGVVKRQ
GEKIAILNFGTLLPEAAAVADKLNATLVDMRFVKPLDTALILQLAGEHDA
LVTLEENAIMGGAGSGVNEVLMAHRRAVPVLNIGLPDYFIPQGTQEEIRA
DLGLDAAGIEAKIRDWLA
3D structure
PDB8bzx Design of thiamine analogues for inhibition of thiamine diphosphate (ThDP)-dependent enzymes: Systematic investigation through Scaffold-Hopping and C2-Functionalisation.
ChainB
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.2.1.7: 1-deoxy-D-xylulose-5-phosphate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SW6 B H49 H80 F107 S123 G151 D152 G153 A154 S184 I185 M312 I334 E336 F361 R364 H48 H79 F106 S122 G150 D151 G152 A153 S183 I184 M294 I316 E318 F343 R346
BS02 MG B D152 N181 M183 D151 N180 M182
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008661 1-deoxy-D-xylulose-5-phosphate synthase activity
Biological Process
GO:0016114 terpenoid biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8bzx, PDBe:8bzx, PDBj:8bzx
PDBsum8bzx
PubMed37201323
UniProtA6T5F3|DXS_KLEP7 1-deoxy-D-xylulose-5-phosphate synthase (Gene Name=dxs)

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