Structure of PDB 8blo Chain B

Receptor sequence
>8bloB (length=352) Species: 9606 (Homo sapiens) [Search protein sequence]
LSKAVGYLTGDMKEYRIWLKDKHLALQFIDWVLRGTAQVMFINNPLSGLI
IFIGLLIQNPWWTITGGLGTVVSTLTALALGQDRSAIASGLHGYNGMLVG
LLMAVFSEKLDYYWWLLFPVTFTAMSCPVLSSALNSIFSKWDLPVFTLPF
NIAVTLYLAATGHYNLFFPTTLVEPVSSVPNITWTEMEMPLLLQAIPVGV
GQVYGCDNPWTGGVFLVALFISSPLICLHAAIGSIVGLLAALSVATPFET
IYTGLWSYNCVLSCIAIGGMFYALTWQTHLLALICALFCAYMEAAISNIM
SVVGVPPGTWAFCLATIIFLLLTTNNPAIFRLPLSKVTYPEANRIYYLTV
KS
3D structure
PDB8blo Structural characterization of human urea transporters UT-A and UT-B and their inhibition.
ChainB
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LMN B I154 Y202 W204 I64 Y112 W114
BS02 LMN B W204 F208 W114 F118
BS03 LMN B L315 L318 L225 L228
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0015204 urea transmembrane transporter activity
GO:0050839 cell adhesion molecule binding
Biological Process
GO:0015840 urea transport
GO:0055085 transmembrane transport
GO:0071918 urea transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016324 apical plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8blo, PDBe:8blo, PDBj:8blo
PDBsum8blo
PubMed37774028
UniProtQ15849|UT2_HUMAN Urea transporter 2 (Gene Name=SLC14A2)

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