Structure of PDB 8biq Chain B

Receptor sequence
>8biqB (length=561) Species: 399549 (Metallosphaera sedula DSM 5348) [Search protein sequence]
VQDFFRKFIEFQNSPNEKSLQEIVKLVGQLDLRRFNWVRDVFEDIHVKER
GSKTALIWRDINTGEEAKLSYHELSLMSNRVLSTLRKHGLKKGDVVYLMT
KVHPMHWAVFLAVIKGGFVMVPSATNLTVAEMKYRFSDLKPSAIISDSLR
ASVMEEALGSLKVEKFLIDGKRETWNSLEDESSNAEPEDTRGEDVIINYF
TSGTTGMPKRVIHTAVSYPVGSITTASIVGVRESDLHLNLSATGWAKFAW
SSFFSPLLVGATVVGINYEGKLDTRRYLGEVENLGVTSFCAPPTAWRQFI
TLDLDQFRFERLRSVVSAGEPLNPEVIKIWKDKFNLTIRDFYGQTETTAM
VGNFPFLKVKPGSMGKPHPLYDIRLLDDEGKEITKPYEVGHITVKLNPRP
IGLFLGYSDEKKNMESFREGYYYTGDKAYFDEEGYFYFVGRGDDVIKTSD
YRVGPFEVESALLEHPAVAEAAVVGVPDTVRWQLVKAYIVLKKGYMPSKE
LAEEIREKMKTLLSPYKVPRIIEFVDELPKTISGKIRRVELRKREEEKRK
KGEVGQNEYVF
3D structure
PDB8biq Crystal structure of acyl-COA synthetase from Metallosphaera sedula in complex with acetyl-AMP
ChainB
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.2.1.1: acetate--CoA ligase.
6.2.1.17: propionate--CoA ligase.
6.2.1.2: medium-chain acyl-CoA ligase.
6.2.1.40: 4-hydroxybutyrate--CoA ligase (AMP-forming).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6R9 B G328 E329 P330 D349 F350 Y351 G352 Q353 T354 D435 F447 K456 R461 G319 E320 P321 D340 F341 Y342 G343 Q344 T345 D426 F438 K447 R452
Gene Ontology
Molecular Function
GO:0003987 acetate-CoA ligase activity
GO:0004321 fatty-acyl-CoA synthase activity
GO:0005524 ATP binding
GO:0015645 fatty acid ligase activity
GO:0016874 ligase activity
GO:0031956 medium-chain fatty acid-CoA ligase activity
GO:0050218 propionate-CoA ligase activity
Biological Process
GO:0006631 fatty acid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0006637 acyl-CoA metabolic process
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:8biq, PDBe:8biq, PDBj:8biq
PDBsum8biq
PubMed
UniProtA4YDT1|HBCL1_METS5 4-hydroxybutyrate--CoA ligase 1 (Gene Name=Msed_0406)

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