Structure of PDB 8bew Chain B

Receptor sequence

>8bewB (length=630) Species: 2325 (Thermoanaerobacter kivui) [Search protein sequence]

MVKLKSIQELENLREKIKEAKKKEKIVIRICGGTGCRASGSLAVRDELVK
VLKREGFANVDVNLSSDCLENTSEVHVKMTGCQGFCAQGPLMTIEPLGVF
YVGVKPEDVEEIVEKSIKKNEIIERLLYHDPATGKTYVKRDENPFYAKQT
RLVLKHCGTVDPASVYDYIAEGGYSAIAKALTMDRKQIIDEVIKSGLRGR
GGAGFPTGEKWLGAYKNQSPKKYIICNGDEGDPGAFMDRSVMEGDPHKVI
EGMMIGAYAIGSDEGYIYVRAEYPLAVQMLRKAIEECEKLGLLGDNILGT
GFSFRLHVREGAGAFVCGESTALTYSIEGKRGMPRVRPPRTNECGLWEMP
TVLNNVETFACIPEIILNGGEWFASIGTPTSTGTKIFALSGKVNRTGLVE
VPMGLKLRELIFDIGGGIANNKKFKAVQLGGPSGGCVPESQLDLPIDFDS
LSKAGAIMGSGGVVVVDEDTCMVDFAKFFTNFIVEESCGKCIPCREGNKK
MLEILERITEGKGKEGDIELLEELGDVIISASLCGLGKTAPNPVLSTIKH
FRDEYEAHIRDKKCPAGACQALAAYKIDPGKCIGCGKCVKVCPVGAISGE
KKKPHVIDQSKCIKCGACAENCPKGAIYKG

3D structure

PDB

8bew Molecular Basis of the Electron Bifurcation Mechanism in the [FeFe]-Hydrogenase Complex HydABC.

Chain

Resolution

3.49 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.12.1.3: hydrogen dehydrogenase (NADP(+)).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	FMN	B	G201 N227 E230 E319 N354 N355 L536	G201 N227 E230 E319 N354 N355 L536
BS02	SF4	B	P334 S487 C488 G489 K490 C491 C494 C534 G537	P334 S487 C488 G489 K490 C491 C494 C534 G537
BS03	ZN	B	C471 H558 C564 C569	C471 H558 C564 C569
BS04	FES	B	C31 G33 C36 C82 Q83 F85 C86	C31 G33 C36 C82 Q83 F85 C86
BS05	SF4	B	Y575 C588 C592 I597 I607 C612 C615 C618	Y575 C588 C592 I597 I607 C612 C615 C618
BS06	SF4	B	I577 C582 I583 C585 C588 C622 K624 A626 I627	I577 C582 I583 C585 C588 C622 K624 A626 I627

Gene Ontology

	Molecular Function
GO:0008137	NADH dehydrogenase (ubiquinone) activity
GO:0010181	FMN binding
GO:0016491	oxidoreductase activity
GO:0046872	metal ion binding
GO:0050583	hydrogen dehydrogenase (NADP+) activity
GO:0051539	4 iron, 4 sulfur cluster binding

	Biological Process
GO:1902600	proton transmembrane transport

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:8bew, PDBe:8bew, PDBj:8bew
PDBsum	8bew
PubMed	36811855
UniProt	A0A097ATG4

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