Structure of PDB 8bcr Chain B

Receptor sequence
>8bcrB (length=258) Species: 11069 (dengue virus type 3) [Search protein sequence]
ETLGEKWKKKLNQLSRKEFDLYKKSGITEVDRTEAKEGLKRGETTHHAVS
RGSAKLQWFVERNMVIPEGRVIDLGCGRGGWSYYCAGLKKVTEVRGYTKG
GPGHEEPVPMSTYGWNIVKLMSGKDVFYLPPEKCDTLLCDIGESSPSPTV
EESRTIRVLKMVEPWLKNNQFCIKVLNPYMPTVIEHLERLQRKHGGMLVR
NPLSRNSTHEMYWISNGTGNIVSSVNMVSRLLLNRFTMTHRRPTIEKDVD
LGAGTRHV
3D structure
PDB8bcr AT-752 targets multiple sites and activities on the Dengue virus replication enzyme NS5.
ChainB
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AT9 B K14 L17 N18 L20 R22 F25 S150 S151 S213 K8 L11 N12 L14 R16 F19 S144 S145 S207
BS02 SAH B S56 G81 G86 W87 T104 K105 H110 E111 K130 D131 V132 F133 D146 S50 G75 G80 W81 T98 K99 H104 E105 K124 D125 V126 F127 D140
Gene Ontology
Molecular Function
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity
GO:0008168 methyltransferase activity
Biological Process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8bcr, PDBe:8bcr, PDBj:8bcr
PDBsum8bcr
PubMed36905944
UniProtA9LIE0

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