Structure of PDB 8bbk Chain B

Receptor sequence
>8bbkB (length=274) Species: 9606 (Homo sapiens) [Search protein sequence]
GKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQ
YDLPYPEAIFELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKG
LLLRLYTQNIDGLERVSGIPASKLVEAHGTFASATCTVCQRPFPGEDIRA
DVMADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGT
SLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGV
ESLVELLGWTEEMRDLVQRETGKL
3D structure
PDB8bbk Molecular Mechanism of Sirtuin 1 Modulation by the AROS Protein.
ChainB
Resolution3.27 Å
3D
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Enzymatic activity
Enzyme Commision number 2.3.1.286: protein acetyllysine N-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B H248 F294 E296 L298 H128 F174 E176 L178
BS02 ZN B C256 C259 C280 C136 C139 C160
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016740 transferase activity
GO:0017136 NAD-dependent histone deacetylase activity
GO:0019899 enzyme binding
GO:0034979 NAD-dependent protein lysine deacetylase activity
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
GO:0070403 NAD+ binding
GO:1990404 NAD+-protein ADP-ribosyltransferase activity
Biological Process
GO:0006338 chromatin remodeling
GO:0006476 protein deacetylation
GO:0009060 aerobic respiration
GO:0032024 positive regulation of insulin secretion
GO:0034983 peptidyl-lysine deacetylation
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:1901671 positive regulation of superoxide dismutase activity
GO:1902553 positive regulation of catalase activity
GO:2000304 positive regulation of ceramide biosynthetic process
GO:2000378 negative regulation of reactive oxygen species metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8bbk, PDBe:8bbk, PDBj:8bbk
PDBsum8bbk
PubMed36361557
UniProtQ9NTG7|SIR3_HUMAN NAD-dependent protein deacetylase sirtuin-3, mitochondrial (Gene Name=SIRT3)

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