Structure of PDB 8b93 Chain B

Receptor sequence
>8b93B (length=241) Species: 9606 (Homo sapiens) [Search protein sequence]
LNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTKSPFVIYDMNSL
MMGEEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYG
VHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFA
VKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQL
KLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETD
3D structure
PDB8b93 Discovery and characterization of orally bioavailable 4-chloro-6-fluoroisophthalamides as covalent PPARG inverse-agonists.
ChainB
Resolution2.21 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B V293 T297 L311 V315 L318 K319 V72 T76 L90 V94 L97 K98
BS02 Q8F B F282 C285 Q286 R288 S289 V293 H323 I326 Y327 L330 F363 H449 L453 F61 C64 Q65 R67 S68 V72 H102 I105 Y106 L109 F142 H228 L232
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8b93, PDBe:8b93, PDBj:8b93
PDBsum8b93
PubMed36542958
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

[Back to BioLiP]