Structure of PDB 8b8x Chain B

Receptor sequence
>8b8xB (length=252) Species: 9606 (Homo sapiens) [Search protein sequence]
QLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTKSPFVIYDMNS
LMMGEDKIKFKHITKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLD
LNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPF
GDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQ
DNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTE
TD
3D structure
PDB8b8x Discovery and characterization of orally bioavailable 4-chloro-6-fluoroisophthalamides as covalent PPARG inverse-agonists.
ChainB
Resolution1.78 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B V293 T297 K301 V315 K319 V83 T87 K91 V105 K109
BS02 A8R B H266 G284 C285 R288 S289 V293 H323 Y327 L330 I341 S342 F363 M364 H449 H62 G74 C75 R78 S79 V83 H113 Y117 L120 I131 S132 F153 M154 H239
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8b8x, PDBe:8b8x, PDBj:8b8x
PDBsum8b8x
PubMed36542958
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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