Structure of PDB 8b8h Chain B

Receptor sequence
>8b8hB (length=371) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
LLAEAMVDLGAIEHNVRVLREHAGHAQLMAVVKADGYGHGATRVAQTALG
AGAAELGVATVDEALALRADGITAPVLAWLHPPGIDFGPALLADVQVAVS
SLRQLDELLHAVRRTGRTATVTVKVDTGLNRNGVGPAQFPAMLTALRQAM
AEDAVRLRGLMSHMVYADKPDDSINDVQAQRFTAFLAQAREQGVRFEVAH
LSNSSATMARPDLTFDLVRPGIAVYGLSPVPALGDMGLVPAMTVKCAVAL
VKSIRAGEGVSYGHTWIAPRDTNLALLPIGYADGVFRSLGGRLEVLINGR
RCPGVGRICMNQFMVDLGPPLDVAEGDEAILFGPGIRGEPTAQDWADLVG
TIHYEVVTSPRGRITRTYREA
3D structure
PDB8b8h Structure of the d-Cycloserine-Resistant Variant D322N of Alanine Racemase from Mycobacterium tuberculosis .
ChainB
Resolution1.78 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.1.1.1: alanine racemase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OJQ B Y273 M321 Y262 M310
BS02 L7N B Y273 M321 Y262 M310
BS03 L7N B V42 K44 Y48 W90 H174 S215 R230 G232 I233 Y366 V31 K33 Y37 W79 H163 S204 R219 G221 I222 Y354
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0008784 alanine racemase activity
GO:0016853 isomerase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0006522 alanine metabolic process
GO:0009252 peptidoglycan biosynthetic process
GO:0030632 D-alanine biosynthetic process
Cellular Component
GO:0005829 cytosol

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Biological Process
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Cellular Component
External links
PDB RCSB:8b8h, PDBe:8b8h, PDBj:8b8h
PDBsum8b8h
PubMed37363078
UniProtP9WQA9|ALR_MYCTU Alanine racemase (Gene Name=alr)

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