Structure of PDB 8b5y Chain B

Receptor sequence
>8b5yB (length=504) Species: 9606 (Homo sapiens) [Search protein sequence]
SRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVT
HIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPL
NCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVR
TGDDKNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVET
LGTVLQLKQPLNTTRINAAEIESRVRELSKLKQGFWEEFETLQQQECKLL
YSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMP
EFKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYW
PDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFR
TWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIV
IDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHY
IETL
3D structure
PDB8b5y Discovery of a Novel Series of Imidazopyrazine Derivatives as Potent SHP2 Allosteric Inhibitors.
ChainB
Resolution1.83 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 P8O B T108 R111 F113 H114 T218 T219 E249 E250 T253 L254 Q257 T106 R109 F111 H112 T213 T214 E237 E238 T241 L242 Q245
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8b5y, PDBe:8b5y, PDBj:8b5y
PDBsum8b5y
PubMed36793438
UniProtQ06124|PTN11_HUMAN Tyrosine-protein phosphatase non-receptor type 11 (Gene Name=PTPN11)

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