Structure of PDB 8b51 Chain B

Receptor sequence
>8b51B (length=260) Species: 64286 (Usutu virus) [Search protein sequence]
RTLGEQWKEKLNGLSKEDFLKYRKEAITEVDRSAARKARRDGNKTGGHPV
SRGSAKLRWMVERQFVKPIGKVVDLGCGRGGWSYYAATLKGVQEVRGYTK
GGPGHEEPMLMQSYGWNLVTMKSGVDVYYKPSEPCDTLFCDIGESSSSAE
VEEQRTLRILEMVSDWLQRGPREFCIKVLCPYMPRVMERLEVLQRRYGGG
LVRVPLSRNSNHEMYWVSGAAGNIVHAVNMTSQVLIGRMEKTWHGPKYEE
DVNLGSGTRA
3D structure
PDB8b51 Usutu virus methyltransferase domain in complex with sinefungin
ChainB
Resolution1.84 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SFG B S57 G82 G87 W88 K106 H111 E112 V131 D132 V133 Y134 D147 I148 S51 G76 G81 W82 K100 H105 E106 V125 D126 V127 Y128 D141 I142
BS02 GLY B R42 R85 R36 R79
Gene Ontology
Molecular Function
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity
GO:0008168 methyltransferase activity
Biological Process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8b51, PDBe:8b51, PDBj:8b51
PDBsum8b51
PubMed36334638
UniProtQ5WPU5|POLG_USUV Genome polyprotein

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