Structure of PDB 8b2j Chain B

Receptor sequence
>8b2jB (length=179) Species: 9606 (Homo sapiens) [Search protein sequence]
NVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLP
LDCGVPDNLSMADPNIRFLDKLPQQTGDRAGIKDRVYSNSIYELLENGQR
AGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAP
ESQNNCRLIAYQEFSLSQEVLRHLRQEEK
3D structure
PDB8b2j Crystal structure of human STING in complex with ADU-S100
ChainB
Resolution2.174 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GJF B S162 Y163 G166 Y167 R232 R238 T263 T267 S9 Y10 G13 Y14 R79 R85 T110 T114
BS02 CA B N187 N188 R191 N34 N35 R38
Gene Ontology
Biological Process
GO:0002218 activation of innate immune response
GO:0032481 positive regulation of type I interferon production

View graph for
Biological Process
External links
PDB RCSB:8b2j, PDBe:8b2j, PDBj:8b2j
PDBsum8b2j
PubMed
UniProtQ86WV6|STING_HUMAN Stimulator of interferon genes protein (Gene Name=STING1)

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