Structure of PDB 8b07 Chain B

Receptor sequence
>8b07B (length=284) Species: 10244 (Monkeypox virus) [Search protein sequence]
DVVSLDKPFMYFEEIDNELDYEPKLPYQGQLKLLLGELFFLSKLQRHGIL
DGATVVYIGSAPGTHIRYLRDHFYNLGVIIKWMLIDGRHHDPILNGLRDV
TLVTRFVDEEYLRSIKKQLHPSKIILISDVRSKEPSTADLLSNYALQNVM
ISILNPVASSLKWRCPFPDQWIKDFYIPHGNKMLQPFAPSYSAEMRLLSI
YTGENMRLTRVTKSDAVNYEKKMYYLNKIVRNKVVINFDYPNQEYDYFHM
YFMLRTVYCNKTFPTTKAKILFLQQSIFRFLNIP
3D structure
PDB8b07 Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase.
ChainB
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.57: methyltransferase cap1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SFG B Q39 L42 G68 S69 A70 P71 G72 H74 D95 R97 V116 D138 V139 R140 Q30 L33 G59 S60 A61 P62 G63 H65 D86 R88 V107 D129 V130 R131
Gene Ontology
Molecular Function
GO:0003746 translation elongation factor activity
GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity
GO:0008168 methyltransferase activity
Biological Process
GO:0006370 7-methylguanosine mRNA capping
GO:0006412 translation
GO:0006414 translational elongation
GO:0031440 regulation of mRNA 3'-end processing
GO:0032259 methylation
Cellular Component
GO:0044423 virion component

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Molecular Function
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Cellular Component
External links
PDB RCSB:8b07, PDBe:8b07, PDBj:8b07
PDBsum8b07
PubMed37080993
UniProtA0A7H0DN74|MCE_MONPV Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase (Gene Name=OPG102)

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