Structure of PDB 8ays Chain B

Receptor sequence
>8aysB (length=117) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence]
EKTHVQLSLPVLQVRDVLVRGFGDSVEEVLSEARQHLKDGTCGLVEVEKG
VLPQLEQPYVFIKRSDARTAPHGHVMVELVAELEGIQYGRSGETLGVLVP
HVGEIPVAYRKVLLRKN
3D structure
PDB8ays Two Ligand-Binding Sites on SARS-CoV-2 Non-Structural Protein 1 Revealed by Fragment-Based X-ray Screening.
ChainB
Resolution1.37 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 92G B R43 L46 K47 K125 R34 L37 K38 K116
External links
PDB RCSB:8ays, PDBe:8ays, PDBj:8ays
PDBsum8ays
PubMed36293303
UniProtP0DTD1|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)

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