Structure of PDB 8ayj Chain B

Receptor sequence

>8ayjB (length=276) Species: 81468 (Aminobacterium colombiense) [Search protein sequence]

HMNLCYIDGKFLPLEEAKLPVTDLIIQRGVGVFETISTHSRRPLMLTPHL
KRLEGSATASSIVMPATLDEMARIIREGIKKMGCETMVRPYITGGDSFGK
DHLFSSSRYFVIFEEIRKPDPILYEKGVALHPINAERYLPSTKSINYMLS
FTGQRDSKGAYEILYCPEGEIVEGSHSTFFLIKNGHLITAPTSRALSGTT
RQIVLELARRGNIQVEERCPLLTELPEAEEAFITGTVKELLPVVRIGDQI
IGNGVPGKLTKHLHQVYLSSIVEWLE

3D structure

PDB

8ayj In search for structural targets for engineering d-amino acid transaminase: modulation of pH optimum and substrate specificity.

Chain

Resolution

1.75 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	OCF	B	F32 T34 R51 R136 Y146 E172 H175 S176 T177 L195 G197 T198 T199 G234 T235	F33 T35 R52 R137 Y147 E173 H176 S177 T178 L196 G198 T199 T200 G235 T236
BS02	PLP	B	R51 Y146 E172 S174 H175 S176 L195 G197 T198 T199 T235	R52 Y147 E173 S175 H176 S177 L196 G198 T199 T200 T236
BS03	OCF	B	T34 M86 R88 R116 K142 Y146 H175 T235 V236 K237	T35 M87 R89 R117 K143 Y147 H176 T236 V237 K238

Gene Ontology

	Molecular Function
GO:0003824	catalytic activity
GO:0008483	transaminase activity

	Biological Process
GO:0019752	carboxylic acid metabolic process
GO:0046394	carboxylic acid biosynthetic process

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:8ayj, PDBe:8ayj, PDBj:8ayj
PDBsum	8ayj
PubMed	37548495
UniProt	D5EHC5

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