Structure of PDB 8au3 Chain B

Receptor sequence
>8au3B (length=281) Species: 9606 (Homo sapiens) [Search protein sequence]
SALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKI
HCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLV
VLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDL
AARNCMLDEKFTVKVADFGLARDMYDLPVKWMALESLQTQKFTTKSDVWS
FGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLK
CWHPKAEMRPSFSELVSRISAIFSTFIGEHY
3D structure
PDB8au3 Biophysical and structural characterization of the impact of c-MET phosphorylation on Tepotinib binding
ChainB
Resolution2.26 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3E8 B I1084 A1108 P1158 Y1159 M1160 K1161 D1164 R1208 M1211 A1221 D1222 Y1230 I29 A53 P103 Y104 M105 K106 D109 R153 M156 A166 D167 Y175
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8au3, PDBe:8au3, PDBj:8au3
PDBsum8au3
PubMed37806493
UniProtP08581|MET_HUMAN Hepatocyte growth factor receptor (Gene Name=MET)

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