Structure of PDB 8asc Chain B

Receptor sequence
>8ascB (length=531) Species: 9606 (Homo sapiens) [Search protein sequence]
NKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQVFAENKDEIA
LVLFGTDGTDNPLSGGDQYQNITVHRHLMLPDFDLLEDIESKIQPGSQQA
DFLDALIVSMDVIQHETIGKKFEKRHIEIFTDLSSRFSKSQLDIIIHSLK
KCDISLQFFLPFSLGKEDGSPFRLGGHGPSFPLKGITEQQKEGLEIVKMV
MISLEGEDGLDEIYSFSESLRKLCVFKKIERHSIHWPCRLTIGSNLSIRI
AAYKSILQERVKKTWTVVDAKTLKKEDIQKETVYCLNDDDETEVLKEDII
QGFRYGSDIVPFSKVDEEQMKYKSEGKCFSVLGFCKSSQVQRRFFMGNQV
LKVFAARDDEAAAVALSSLIHALDDLDMVAIVRYAYDKRANPQVGVAFPH
IKHNYECLVYVQLPFMEDLRQYMFSSLKNSKKYAPTEAQLNAVDALIDSM
SLAKKKTDTLEDLFPTTKIPNPRFQRLFQCLLHRALHPREPLPPIQQHIW
NMLNPPAEVTTKSQIPLSKIKTLFPLIEAKK
3D structure
PDB8asc PAXX binding to the NHEJ machinery explains functional redundancy with XLF.
ChainB
Resolution2.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B T275 R400 R431 T264 R389 R420
BS02 dna B K265 Y397 A401 N402 K254 Y386 A390 N391
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003684 damaged DNA binding
GO:0042162 telomeric DNA binding
Biological Process
GO:0000723 telomere maintenance
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006310 DNA recombination
Cellular Component
GO:0005634 nucleus
GO:0043564 Ku70:Ku80 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8asc, PDBe:8asc, PDBj:8asc
PDBsum8asc
PubMed37256950
UniProtP13010|XRCC5_HUMAN X-ray repair cross-complementing protein 5 (Gene Name=XRCC5)

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