Structure of PDB 8aqn Chain B

Receptor sequence
>8aqnB (length=251) Species: 9606 (Homo sapiens) [Search protein sequence]
ADLRALAKHLYDSYIKSFPLTKAKARAILTGKSPFVIYDMNSLMMGEDKI
KFIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEII
YTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNA
LELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHP
ESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDL
Y
3D structure
PDB8aqn Discovery and Structure-Based Design of Potent Covalent PPAR gamma Inverse-Agonists BAY-4931 and BAY-0069 .
ChainB
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B V293 T297 K301 Q314 V315 L318 K319 H323 V67 T71 K75 Q88 V89 L92 K93 H97
BS02 O0U B F282 C285 Q286 K319 H323 M364 K367 H449 Y473 Y477 F56 C59 Q60 K93 H97 M138 K141 H223 Y247 Y251
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8aqn, PDBe:8aqn, PDBj:8aqn
PDBsum8aqn
PubMed36270630
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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