Structure of PDB 8aq7 Chain B

Receptor sequence
>8aq7B (length=158) Species: 9606 (Homo sapiens) [Search protein sequence]
MTEYKLVVVGACGVGKSALTIQLIQNHEDSYRKQVVIDGETSLLDILDTA
GQEEYSAMRDQYMRTGEGFLLVFAINNTKSFEDIHHYREQIKRVKDSEDV
PMVLVGNKSDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTL
VREIRKHK
3D structure
PDB8aq7 JDQ443, a Structurally Novel, Pyrazole-Based, Covalent Inhibitor of KRAS G12C for the Treatment of Solid Tumors.
ChainB
Resolution1.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NZX B C12 K16 A59 G60 E62 E63 Y64 S65 R68 D69 M72 Y96 Q99 C12 K16 A50 G51 E53 E54 Y55 S56 R59 D60 M63 Y87 Q90
BS02 GDP B G13 V14 G15 K16 S17 A18 N116 K117 D119 L120 S145 A146 K147 G13 V14 G15 K16 S17 A18 N107 K108 D110 L111 S136 A137 K138
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:8aq7, PDBe:8aq7, PDBj:8aq7
PDBsum8aq7
PubMed36399068
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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