Structure of PDB 8an8 Chain B

Receptor sequence
>8an8B (length=263) Species: 9606 (Homo sapiens) [Search protein sequence]
LNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDKKIHCAVK
SEVSQFLTEGIIMKDFSHPNVLSLLGICSPLVVLPYMKHGDLRNFIRNET
HNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADF
GLARDMYDKEYYLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAP
PYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSE
LVSRISAIFSTFI
3D structure
PDB8an8 Discovery of a selective c-MET inhibitor with a novel binding mode
ChainB
Resolution2.394 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MDI B I1084 A1108 K1110 E1120 V1121 S1122 L1125 L1157 P1158 M1160 D1222 F1223 G1224 I27 A48 K50 E52 V53 S54 L57 L84 P85 M87 D149 F150 G151
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8an8, PDBe:8an8, PDBj:8an8
PDBsum8an8
PubMed35987508
UniProtP08581|MET_HUMAN Hepatocyte growth factor receptor (Gene Name=MET)

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