Structure of PDB 8alk Chain B

Receptor sequence
>8alkB (length=163) Species: 9606 (Homo sapiens) [Search protein sequence]
MPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTVDFKIRTIELDGKTIKL
QIWDTAGQERFRTITSTYYRGAHGIIVVYDVTDQESYANVKQWLQEIDRY
AENVNKLLVGNKSDLTTKKVVDNTTAKEFADSLGIPFLETSAKNATNVEQ
AFMTMAAEIKKRM
3D structure
PDB8alk Dephosphocholination by Legionella effector Lem3 functions through remodelling of the switch II region of Rab1b.
ChainB
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP B G18 G20 K21 S22 C23 Y33 K122 D124 L125 S151 A152 K153 G17 G19 K20 S21 C22 Y32 K112 D114 L115 S141 A142 K143
BS02 CA B S22 D44 D63 S21 D35 D54
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:8alk, PDBe:8alk, PDBj:8alk
PDBsum8alk
PubMed37076474
UniProtQ9H0U4|RAB1B_HUMAN Ras-related protein Rab-1B (Gene Name=RAB1B)

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