Structure of PDB 8akd Chain B

Receptor sequence
>8akdB (length=277) Species: 9606 (Homo sapiens) [Search protein sequence]
KGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDF
RGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQN
VDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGR
LCTVACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRP
SGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHLGL
EIPAWDGPRVLERALPPLPRPPTPKLE
3D structure
PDB8akd Development of novel Sirtuin 6 inhibitors and activators based on a protein crystallography-based fragment screen
ChainB
Resolution1.76 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.286: protein acetyllysine N-acetyltransferase.
2.4.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AR6 B G52 A53 G54 T57 D63 F64 R65 Q113 H133 G214 T215 S216 I219 N240 L241 Q242 Y257 V258 G38 A39 G40 T43 D49 F50 R51 Q99 H119 G193 T194 S195 I198 N219 L220 Q221 Y236 V237
BS02 ZN B C141 C144 C166 C177 C127 C130 C152 C156
BS03 HIC B L186 L192 R220 L165 L171 R199
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:8akd, PDBe:8akd, PDBj:8akd
PDBsum8akd
PubMed
UniProtQ8N6T7|SIR6_HUMAN NAD-dependent protein deacylase sirtuin-6 (Gene Name=SIRT6)

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