Structure of PDB 8ajj Chain B

Receptor sequence
>8ajjB (length=391) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
DLIVIGFGKAGKTLAKYAASTGQHVAVIEQLLADDNNIDVLDFKAQFKSN
TEVNLLDQHDDIVDSITAPHIIINTGATSVIPNIKGLDQAKHVFDSTGLL
NISYQPKHLVIVGGGYIALEFASMFANLGSKVTVLERGESFMPREDQDVV
AYGITDLENKGIALHTNVETTELSSDNHHTTVHTNVDNFEADAVLLAIGR
KPNTDLALENTDIELGDRGEIKVNAHLQTTVPHIYAAGDVKGGLQFTYIS
LDDYRIIKSALYGNQSRTTDNRGSVPYTVFIDPPLSRVGLTSKEAAAQHY
DYTEHQLLVSAIPRHKINNDPRGLFKVVINNENNMILGATLYGKQSEELI
NIIKLAIDQNIPYTVLRDNIYTHPTMAESFNDLFNFHHHHH
3D structure
PDB8ajj MerA functions as a hypothiocyanous acid reductase and defense mechanism in Staphylococcus aureus.
ChainB
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.-.-.-
1.16.1.1: mercury(II) reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD B G12 E33 T129 G130 I171 N257 G292 D293 Q299 F300 T301 Y302 G8 E29 T75 G76 I117 N203 G238 D239 Q245 F246 T247 Y248
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004791 thioredoxin-disulfide reductase (NADPH) activity
GO:0016491 oxidoreductase activity
GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
Biological Process
GO:0045454 cell redox homeostasis
GO:0098869 cellular oxidant detoxification
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:8ajj, PDBe:8ajj, PDBj:8ajj
PDBsum8ajj
PubMed36779383
UniProtQ2G0I4

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