Structure of PDB 8afc Chain B

Receptor sequence
>8afcB (length=149) Species: 9606 (Homo sapiens) [Search protein sequence]
TEYKLVVVGACGVGKSALTIQLIQNHFVDESYRKQVVIDGETCLLDILDT
QYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKSD
LPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHKE
3D structure
PDB8afc Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRAS G12C Inhibitor.
ChainB
Resolution2.41 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP B G13 V14 G15 K16 S17 A18 F28 N116 K117 D119 S145 A146 G12 V13 G14 K15 S16 A17 F27 N97 K98 D100 S126 A127
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8afc, PDBe:8afc, PDBj:8afc
PDBsum8afc
PubMed36300829
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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