Structure of PDB 8ab3 Chain B

Receptor sequence
>8ab3B (length=328) Species: 379064 (Cyanobacterium aponinum) [Search protein sequence]
FEKILLSNPSAENPSSLRPRKGIIIGLGQVGLACAYSMLIQDCFDELVLQ
DIASDKLEGEVMDFSHGMPFIPPTDIKAGTIANEGRNADIVIITAGVAQK
EGESRLSLLERNIAIYKKILADVVKYCPEAIILVVTNPVDIMTYATLKIT
GFPSSRIIGSGTVLDTARFRTLLAKEMDIDPRSVHAYIIGEHGDSEVPVW
STANVGGMKLVPNTWADLPEDEKATLSGIFQKVQNAAYDIIKLKGYTSYA
IGLATTDIVKAILNSQERILTVSGLMTGMYGIEDVCLSIPRVVSERGIIK
TVNLTLSEDEEKLLQQSAKMLKEVFDKI
3D structure
PDB8ab3 Crystal Structure of the Lactate Dehydrogenase of Cyanobacterium Aponinum in complex with oxamate, NADH and FBP.
ChainB
Resolution2.616 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.27: L-lactate dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FBP B R173 H188 R170 H185
BS02 NAI B G31 Q32 V33 D54 I55 T97 A98 V100 A101 V138 N140 H195 I254 G28 Q29 V30 D51 I52 T94 A95 V97 A98 V135 N137 H192 I251
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003824 catalytic activity
GO:0004459 L-lactate dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Biological Process
GO:0006089 lactate metabolic process
GO:0006090 pyruvate metabolic process
GO:0006096 glycolytic process
GO:0019752 carboxylic acid metabolic process
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:8ab3, PDBe:8ab3, PDBj:8ab3
PDBsum8ab3
PubMed37797308
UniProtK9Z684

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