Structure of PDB 8a4d Chain B

Receptor sequence
>8a4dB (length=558) Species: 557722 (Pseudomonas aeruginosa LESB58) [Search protein sequence]
HEIPRERPATPLLDRASSPAELRRLGEADLETLADELRQYLLYTVGQTGG
HFGAGLGVVELTIALHYVFDTPDDRLVWDVGHQAYPHKILTERRELMGTL
RQKNGLAAFPRRAESEYDTFGVGHSSTSISAALGMAIAARLQGKERKSVA
VIGDGALTAGMAFEALNHASEVDADMLVILNDNDMSGTLFEELGWNYIGP
IDGHDLPTLVATLRNMRDMKGPQFLHVVTKKGKGFAPAELDPIGYHAITK
LETGGPKYSSVFGQWLCDMAAQDARLLGITPAMKEGSDLVAFSERYPERY
FDVAIAEQHAVTLAAGMACEGMKPVVAIYSTFLQRAYDQLIHDVAVQHLD
VLFAIDRAGLVGEDGPTHAGSFDISYLRCIPGMLVMTPSDEDELRKLLTT
GYLFDGPAAVRYPRGSGPNHPIDPDLQPVEIGKGVVRRRGGRVALLVFGV
QLAEAMKVAESLDATVVDMRFVKPLDEALVRELAGSHELLVTIEENAVMG
GAGSAVGEFLASEGLEVPLLQLGLPDYYVEHAKPSEMLAECGLDAAGIEK
AVRQRLDR
3D structure
PDB8a4d 1-deoxy-D-xylulose-5-phosphate synthase from Pseudomonas aeruginosa and Klebsiella pneumoniae reveals conformational changes upon cofactor binding.
ChainB
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.2.1.7: 1-deoxy-D-xylulose-5-phosphate synthase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 26G B H115 H157 S158 M346 I368 E370 F395 R398 H82 H124 S125 M283 I305 E307 F332 R335
BS02 MG B D187 N216 D154 N183
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008661 1-deoxy-D-xylulose-5-phosphate synthase activity
Biological Process
GO:0016114 terpenoid biosynthetic process

View graph for
Molecular Function

View graph for
Biological Process
External links
PDB RCSB:8a4d, PDBe:8a4d, PDBj:8a4d
PDBsum8a4d
PubMed37567475
UniProtB7V7R4|DXS_PSEA8 1-deoxy-D-xylulose-5-phosphate synthase (Gene Name=dxs)

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