Structure of PDB 8a3w Chain B

Receptor sequence

>8a3wB (length=395) Species: 347515 (Leishmania major strain Friedlin) [Search protein sequence]

HPRHGHLGFLPRKRSRQIRGRARAFPKDDATQKPHLTSFMVFKAGMTHIV
RDVDRPGSKVNKKEVVEPVTILEAPPMVIVGIVGYRQTPVGLKTIGTVWA
HHTSVEFRRRYYKNWKQSAQLAFSRQKQFANTKEGKVAEARTLNAFAKKA
SVIRVIAHTQLRKLRNHRVGVKKAHVQEIQVNGGSVAAKIALAKSLLEKE
VRVDSVFQQSEACDVCSVTKGHGTEGVVKRWGVACLPRKTHRGLRKVACI
GAWHPARVMYTVARAGQHGYHHRTQLNKKIYQIGRSVAVEPNQATTTYDL
TAKTITPMGGFVGYGTVRNDYVMLKGSVSGPRRRVMTLRRPMAPQTSRQL
KEKIVLKFIDTSSKIGHGRFQTKKEKNQWFGPLKKDRIRREERLR

3D structure

PDB

8a3w CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : WILD TYPE

Chain

Resolution

2.89 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	B	R10 H11 R19 K20 R21 R93 P96 N151 T231 G233 R237 K246 T247 H248 R249 G250 R252 A255 C256 A259 W260 H261 A263 R264 V265 T268 R271 A272 Q274	R3 H4 R12 K13 R14 R86 P89 N144 T224 G226 R230 K239 T240 H241 R242 G243 R245 A248 C249 A252 W253 H254 A256 R257 V258 T261 R264 A265 Q267
BS02	rna	B	R21 R117 Y119 K120 N121 K123 A126 R175 G177 V178 K179 K180 G228 Y277 G316 G320 G322 R325 R340 R341 S370 I372 K380 K383 F387 K391	R14 R110 Y112 K113 N114 K116 A119 R168 G170 V171 K172 K173 G221 Y270 G309 G313 G315 R318 R333 R334 S363 I365 K373 K376 F380 K384
BS03	rna	B	G12 H13 L14 G15 R26 R30 K50 M53 H55 R62 P75 Y92 L99 T101 I102 G103 T104 W106 L128 A129 F130 R132 R161 E185 T226 K227 H279 R280 T281 L283 V335 S336 G373	G5 H6 L7 G8 R19 R23 K43 M46 H48 R55 P68 Y85 L92 T94 I95 G96 T97 W99 L121 A122 F123 R125 R154 E178 T219 K220 H272 R273 T274 L276 V328 S329 G366

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome

	Biological Process
GO:0006412	translation

	Cellular Component
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8a3w, PDBe:8a3w, PDBj:8a3w
PDBsum	8a3w
PubMed
UniProt	Q4Q2Q6

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