Structure of PDB 8a1s Chain B

Receptor sequence
>8a1sB (length=533) Species: 10090 (Mus musculus) [Search protein sequence]
TGFQICKNALKLPVLEVLPGGGWDNLRNVDMGRVMDLTYTNCKTTEDGQY
IIPDEVYTIPQKESNLEMNSEVLESWMNYQSTTSLSINTELALFSRVNGK
FSTEFQRMKTLQVKDQAVTTRVQVRNRIYTVKTTPTSELSLGFTKALMDI
CDQLEKNQTKMATYLAELLILNYGTHVITSVDAGAALVQEDHVRSSFLLD
NQNSQNTVTASAGIAFLNIVNFKVETDYISQTSLTKDYLSNRTNSRVQSF
GGVPFYPGITLETWQKGITNHLVAIDRAGLPLHFFIKPDKLPGLPGPLVK
KLSKTVETAVRHYYTFNFTFGGVYQECTELSGDVLCQNLEQKNLLTGDFS
CPPGYSPVHLLSQTHEEGYSRLECKKKCTLKIFCKTVCEDVFRVAKAEFR
AYWCVAAGQVPDNSGLLFGGVFTDKTINPMTNAQSCPAGYIPLNLFESLK
VCVSLDYELGFKFSVPFGGFFSCIMGNPLVNAPSLKKCPGGFSQHLAVIS
DGCQVSYCVKAGIFTGGSLLPVRLPPYTKPPLM
3D structure
PDB8a1s Cryo-EM structures of perforin-2 in isolation and assembled on a membrane suggest a mechanism for pore formation.
ChainB
Resolution4.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MA4 B M105 Y266 G426 Y427 S428 M77 Y238 G368 Y369 S370
Gene Ontology
Molecular Function
GO:0022829 wide pore channel activity
GO:0140911 pore-forming activity
Biological Process
GO:0002250 adaptive immune response
GO:0002468 dendritic cell antigen processing and presentation
GO:0002478 antigen processing and presentation of exogenous peptide antigen
GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042742 defense response to bacterium
GO:0045087 innate immune response
GO:0050829 defense response to Gram-negative bacterium
GO:0050830 defense response to Gram-positive bacterium
GO:0055085 transmembrane transport
GO:0140367 antibacterial innate immune response
Cellular Component
GO:0016020 membrane
GO:0030670 phagocytic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0036019 endolysosome
GO:0045335 phagocytic vesicle
GO:0061474 phagolysosome membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8a1s, PDBe:8a1s, PDBj:8a1s
PDBsum8a1s
PubMed36245269
UniProtA1L314|MPEG1_MOUSE Macrophage-expressed gene 1 protein (Gene Name=Mpeg1)

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