Structure of PDB 8a15 Chain B

Receptor sequence
>8a15B (length=150) Species: 64320 (Zika virus) [Search protein sequence]
TTDGVYRVMTRSTQVGVGVMQEGVFHTMWHVTKGAALRSGEGRLDPYWGD
VKQDLVSYCGPWKLDAAWDGLSEVQLLAVPPGERAKNIQTLPGIFKTKDG
DIGAVALDYPAGTSGSPILDKCGRVIGLYGNGVVIKNGSYVSAITQGKRE
3D structure
PDB8a15 Crystal Structure of Unlinked NS2B-NS3 Protease from Zika Virus in Complex with Inhibitor MI-2230
ChainB
Resolution1.23 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KPO B H51 D129 Y130 A132 S135 G151 N152 G153 V154 V155 Y161 H30 D108 Y109 A111 S114 G130 N131 G132 V133 V134 Y140
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:8a15, PDBe:8a15, PDBj:8a15
PDBsum8a15
PubMed38809037
UniProtQ32ZE1|POLG_ZIKV Genome polyprotein

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