Structure of PDB 8a0g Chain B

Receptor sequence
>8a0gB (length=344) Species: 9606 (Homo sapiens) [Search protein sequence]
APAGALAAVLKHSSTLPPESTQVRGYDFNRGVNYRALLEAFGTTGFQATN
FGRAVQQVNAMIEKKLEPLQSRRPLTSCTIFLGYTSNLISSGIRETIRYL
VQHNMVDVLVTTAGGVEEDLIKCLAPTYLGEFSLRGKELRENGINRIGNL
LVPNENYCKFEDWLMPILDQMVMEQNTEGVKWTPSKMIARLGKEINNPES
VYYWAQKNHIPVFSPALTDGSLGDMIFFHSYKNPGLVLDIVEDLRLINTQ
AIFAKCTGMIILGGGVVKHHIANANLMRNGADYAVYINTAQEFDGSDSGA
RPDEAVSWGKIRVDAQPVKVYADASLVFPLLVAETFAQKMDAFM
3D structure
PDB8a0g Cryo-EM structure of human eIF5A-DHS complex reveals the molecular basis of hypusination-associated neurodegenerative disorders.
ChainB
Resolution1.84 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.46: deoxyhypusine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 13D B G239 S240 D243 G220 S221 D224
BS02 NAD B G284 H288 D313 S315 D316 S317 G265 H269 D294 S296 D297 S298
BS03 NAD B T104 S105 N106 T131 A132 G133 E137 D238 G282 G283 N307 T308 A309 D342 A343 T85 S86 N87 T112 A113 G114 E118 D219 G263 G264 N288 T289 A290 D323 A324
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0034038 deoxyhypusine synthase activity
GO:0042802 identical protein binding
Biological Process
GO:0006412 translation
GO:0008216 spermidine metabolic process
GO:0008284 positive regulation of cell population proliferation
GO:0008612 peptidyl-lysine modification to peptidyl-hypusine
GO:0042102 positive regulation of T cell proliferation
GO:0042593 glucose homeostasis
GO:0046203 spermidine catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8a0g, PDBe:8a0g, PDBj:8a0g
PDBsum8a0g
PubMed36973244
UniProtP49366|DHYS_HUMAN Deoxyhypusine synthase (Gene Name=DHPS)

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