Structure of PDB 7zvs Chain B

Receptor sequence
>7zvsB (length=296) Species: 6183 (Schistosoma mansoni) [Search protein sequence]
RKPFEELCTELADLDMPAENIVLNRRVGQGAFGLVFGGEAKKSDLWEAVA
VKVINEKANYEGKIDFLSEAKLMRSLNHPNVVRLIGISLNPKASLYLIME
LMLLGDLKTYLLSRRILAQRSPNHEDIRPSTLTQMSMDIGQGLAYLHSKH
LIHRDIACRNCLVAADRTVKIGDFGLTRQELPIRWMSPEAVQFGVFSIQS
DIWSFGITLYEIITFGVFPYNGLGDVEVVERVKRMEFSITEFLPPQALNT
VVCELINHCCKHQWQHRPSSMNQVLEVLIAYPDCIRPFLTDDPPKP
3D structure
PDB7zvs Identification of Inhibitors of the Schistosoma mansoni VKR2 Kinase Domain.
ChainB
Resolution3.07 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP B V972 A976 V980 A995 M1047 N1105 L1107 D1118 V27 A31 V35 A50 M102 N160 L162 D173
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:7zvs, PDBe:7zvs, PDBj:7zvs
PDBsum7zvs
PubMed36385939
UniProtA0A3Q0KQ92

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