Structure of PDB 7zv4 Chain B

Receptor sequence
>7zv4B (length=151) Species: 64320 (Zika virus) [Search protein sequence]
ETTDGVYRVMTRGSTQVGVGVMQEGVFHTMWHVTKGAALRSGEGRLDPYW
GDVKQDLVSYCGPWKLDAAWDGLSEVQLLAVPPGERAKNIQTLPGIFKTK
DGDIGAVALDYPAGTSGSPILDKCGRVIGLYGNGVVIKNGSYVSAITQGK
R
3D structure
PDB7zv4 Crystal Structure of Unlinked NS2B-NS3 Protease from Zika Virus in Complex with Inhibitor MI-2195
ChainB
Resolution1.69 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IBW B H51 D129 Y130 P131 A132 S135 G151 N152 G153 V155 Y161 H32 D110 Y111 P112 A113 S116 G132 N133 G134 V136 Y142
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:7zv4, PDBe:7zv4, PDBj:7zv4
PDBsum7zv4
PubMed38809037
UniProtQ32ZE1|POLG_ZIKV Genome polyprotein

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