Structure of PDB 7zol Chain B

Receptor sequence

>7zolB (length=1702) Species: 45655 (Desulfonema magnum)

QHIIPLTITFLESFRVIEWHKSSDRNSLRFLRGYAYARWHRSLKNNKGRP
YITGTLVRSAIIRAAEELLWLNDGNYKGAICCPGEFNGSNAKVFREGKAR
RLRRRQTLTWPTKCACHEKEPCPFCLLLGRYEKSSKTSKSPVLNNVNFSN
FNVLGKEKEFLNIEDVADMRVVNRVDQQSGKAEDFFNIWEITDGAWKIFR
GEIQVSDKGWSDEENFSKFLTLLKGASVLVDKISGGLCYLTLDKPELALE
PGDDASVLEISRPPYWNNMLNLAGTISEAFEREDKLVHLRLFADTVRELR
RSDIETLDLPKGHADRLGKPSDHFIWDIEINKKVKLRNWLFWIFNEFRDT
YAYFDWRTFCEALGQALYLEAKKQVPNQFSSERPVGATPAMEVKTPEHDP
GRAAQGPRYEWLIKGELVSQTPFFFGWSTEATNLKLLAARDGRLRLPLSV
LRGILRRDIKVVLDNKCRAELAMKQPCSCPVCNLMKKITIRDSFSSNYAE
PPKIRHKIRLDPKSGTVAKGALFDSEVGPRGVVFPFELRLRSADDTLPQA
LKTVFSWWQQGTVSFSGDAGTGKGIFCLRNLKSIRWDLKTEMDKYAATLG
GRKTPVGKWDKCHIPDDKTYPWVKETVEISVCSPFITKDPVNSLIDSAGY
DAICYTTVDLEKKDIYLLKGESFRGMLRTAVGRGENLLLREHEDCSCTLC
RIFGNEHNAGKIRVEDFIIQGEPRTKLVDRVAIDRFTAGAKDKFKFDAAP
IVGTPTNKLKFRGNIWIHRDLDGLACESLKLALEDIENGLYPFGGLGNAG
FGWVNYNPLSHPAQEENKADFSLTKKMELNWSMKELSTDKIYWPHYFLPF
GKKVLREKTPPSHACIDENEDSELYSGKIVCTLETRTPLIIPDSEFQGEE
HKSYDFFNLNGELCIPGSEIRGMISSVFEALTNSCMRIFDEKKRLSWRMN
PNKNRRELDDFIPGRVTNDRKMEEMKEYRYPFYDQAITANDKQNKYFDQW
EATIELTDESLEKLKAEKILQSVLDALRPLTKKKEKYKNTETFVFDLKKF
IGKIDDNQQMISEALERGKVRLTGNSLKQISKTKKIPRQILNQLKGLKDN
TYENREQFISVLKTTVRGINDEQISLILDNIDEDVRLTDLSLTKIRKAKV
PQTLVDMLADLKKDEPYKNEKEFLSEFKKKMGEIIGLILKHAAKTGGDVP
RYNHPTPTDKMLLSLAAYNRNHKHENGKAEYRIVKPKHNLKVDFMFAVTY
LKVSGPNKIEKVKKVNPNSVSVRDDKNQEIIHNGVYLRKITVANAKSKNK
LRERLVPEFAWYDKSEAAYAMTKRCERVFVEIGAKPIPIQPSAREKFKIL
TQEYQKNAKQQKTPEAFQTILPKDGELRPGDLVYFREDKKTNTVTDIIPV
RISRTVDDEVLARKIPDDVGDVRPCVREILDKEKQKEIADAGVKEVFQHH
PDGLCPACSLFGTTFYKGRIAFGFAFHKDKDPELANNGKHITLPLLERPR
PTWSMPKKESRVPGRKFYVHHQGWERVIKHSNLDESDPNATKQTVNNRSV
QAIKEEQKFQFEVRFENLREWELGLLVYVLQLEPQFAHKLGMGKALGFGS
VRIRVGEIHSGPKELDESRLVSSAMKKMEEIWDRDKNVLEKLFRLLYFNE
SKDIKVRYPKLQKEKEEEEEESGYMELAKEEYQPEQRRNKLTNPWEGWGN
IL

3D structure

• PDB: 7zol Structural insights into the regulation of Cas7-11 by TPR-CHAT.
• Chain: B
• Resolution: 3.03 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	B	R47 Y49 A50 Y51 H55 R64 Y66 T70 L71 R73 S74 E100 F101 N102 G103 S104 R110 R116 L117 R118 R119 R145 S149 F163 N165 V186 V187 N188 R189 V190 G195 A197 F200 F201 G250 V419 G452 L479 R483 L502 K517 T520 I521 I539 R540 L541 T547 V548 F554 G598 K669 P671 S734 R736 M738 N767 E768 N770 D791 R792 V793 I795 R797 A800 F808 G857 N860 P954 S980 E981 R983 R999 R1010 E1109 R1269 Y1270 K1352 K1385 R1393 K1413 R1414 C1415 R1417 N1447 T1459 I1460 V1490 R1491 I1492 R1494 T1553 T1554 G1558 L1586 E1587 R1588 P1589 R1590 Y1608 K1684 Y1748 Y1764 M1765	R32 Y34 A35 Y36 H40 R49 Y51 T55 L56 R58 S59 E85 F86 N87 G88 S89 R95 R101 L102 R103 R104 R130 S134 F148 N150 V171 V172 N173 R174 V175 G180 A182 F185 F186 G235 V393 G426 L448 R452 L471 K486 T489 I490 I508 R509 L510 T516 V517 F523 G567 K638 P640 S672 R674 M676 N705 E706 N708 D729 R730 V731 I733 R735 A738 F746 G795 N798 P892 S918 E919 R921 R937 R948 E1041 R1201 Y1202 K1263 K1296 R1304 K1323 R1324 C1325 R1327 N1357 T1369 I1370 V1400 R1401 I1402 R1404 T1463 T1464 G1468 L1496 E1497 R1498 P1499 R1500 Y1518 K1594 Y1658 Y1674 M1675
BS02	ZN	B	C997 C1545 C1548	C935 C1455 C1458
BS03	ZN	B	C131 C137 C140	C116 C122 C125
BS04	ZN	B	H754 C757 C759 C762	H692 C695 C697 C700

Gene Ontology

Biological Process

• GO:0051607 defense response to virus

External links

• PDB: RCSB:7zol, PDBe:7zol, PDBj:7zol
• PDBsum: 7zol
• PubMed: 36471056
• UniProt: A0A975GRY4