Structure of PDB 7zmb Chain B

Receptor sequence

>7zmbB (length=456) Species: 759272 (Thermochaetoides thermophila DSM 1495)

VRTYGGLKDQDRIFQNLYGRYPPDLKHAKKMGDWYKTKEILLKGHDWIIG
EIKASGLRGRGGAGFPSGLKWSFMNFKDWDKDNKPRYLVVNADEGEPGTC
KDREIMRKDPHKLVEGCLVAGRAMNATAAYIYIRGEFYQEAAILQNAINE
AYAEGLIGKNACGSGYDFDVYIHRGAGAYVCGEETSLIESLEGKPGKPRL
KPPFPAAVGLFGCPSTVANVETVSVAPTICRRGGAWFASFGRERNHGTKL
FCISGHVNNPCTVEEEMSIPMRELIEKHCGGVRGGWDNLLAVIPGGSSTP
ILPKHICDDQLMDFDALKDSQSGLGTAAVIVMDKSTDVVRAISRLSHFYR
HESCGQCTPCREGSKWTDQIMKRFEKGMGRPREIDMLQELTKQVEGHTIC
ALGEAFAWPIQGLIRHFRPELEARMKKFAEETGGQALAGGWTHDSRQKGR
LVSPGM

3D structure

• PDB: 7zmb Conformational changes in mitochondrial complex I of the thermophilic eukaryote Chaetomium thermophilum.
• Chain: B
• Resolution: 2.75 Å

Enzymatic activity

• Enzyme Commision number: 7.1.1.2: NADH:ubiquinone reductase (H(+)-translocating).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	SF4	B	S404 C405 G406 C408 C411 C451 L453	S353 C354 G355 C357 C360 C400 L402
BS02	FMN	B	G110 G112 K121 N142 E145 Y230 G233 E234 E235 V268 A269 N270	G59 G61 K70 N91 E94 Y179 G182 E183 E184 V217 A218 N219

Gene Ontology

Molecular Function

• GO:0008137 NADH dehydrogenase (ubiquinone) activity
• GO:0010181 FMN binding
• GO:0046872 metal ion binding
• GO:0051287 NAD binding
• GO:0051539 4 iron, 4 sulfur cluster binding

Biological Process

• GO:1902600 proton transmembrane transport

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0045271 respiratory chain complex I

External links

• PDB: RCSB:7zmb, PDBe:7zmb, PDBj:7zmb
• PDBsum: 7zmb
• PubMed: 36427319
• UniProt: G0SA46