Structure of PDB 7zlt Chain B

Receptor sequence
>7zltB (length=405) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
SPNLPPGFDFTDPAIYAERLPVAEFAELRSAAPIWWNGQDPGKGGGFHDG
GFWAITKLNDVKEISRHSDVFSSYENGVIPRFKNDIAREDIEVQRFVMLN
MDAPHHTRLRKIISRGFTPRAVGRLHDELQERAQKIAAEAAAAGSGDFVE
QVSCELPLQAIAGLLGVPQEDRGKLFHWSNEMTGNEDPEYAHIDPKASSA
ELIGYAMKMAEEKAKNPDIVTQLIQADDGEKLSDDEFGFFVVMLAVAGNE
TTRNSITQGMMAFAEHPDQWELYKKVRPETAADEIVRWATPVTAFQRTAL
RDYELSGVQIKKGQRVVMFYRSANFDEEVFQDPFTFNILRNPNPHVGFGG
TGAHYCIGANLARMTINLIFNAVADHMPDLKPISAPERLRSGWLNGIKHW
QVDYT
3D structure
PDB7zlt Crystal structure of CYP125 from Mycobacterium tuberculosis in complex with an inhibitor
ChainB
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.15.29: cholest-4-en-3-one 26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming].
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 JFI B V111 V115 S217 M264 V267 A268 T272 W414 V93 V97 S199 M243 V246 A247 T251 W393
BS02 HEM B L117 H124 R128 M264 L265 A268 G269 T272 P312 F316 R318 G368 F369 G370 H375 C377 G379 L99 H106 R110 M243 L244 A247 G248 T251 P291 F295 R297 G347 F348 G349 H354 C356 G358
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0008395 steroid hydroxylase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0036199 cholest-4-en-3-one 26-monooxygenase activity
GO:0046872 metal ion binding
Biological Process
GO:0006707 cholesterol catabolic process
GO:0008203 cholesterol metabolic process
GO:0016042 lipid catabolic process
GO:0051701 biological process involved in interaction with host

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Molecular Function
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Biological Process
External links
PDB RCSB:7zlt, PDBe:7zlt, PDBj:7zlt
PDBsum7zlt
PubMed
UniProtP9WPP1|CP125_MYCTU Steroid C26-monooxygenase (Gene Name=cyp125)

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