Structure of PDB 7zk3 Chain B

Receptor sequence
>7zk3B (length=721) Species: 10090 (Mus musculus) [Search protein sequence]
MDYHEDDKRFRREELCREAEFLKLKMPTKKVYHISETRGLLKTINSVLQK
ITDPIQPKVAEHRPQTTKRLSYPFSREKQHLFDLTDRDSFFDSKTRSTIV
YEILKRTTCGITSLLANGVYSAAYPLHDGDYEGDNVEFNDRKLLYEEWAS
YGVFYKYQPIDLVRKYFGEKVGLYFAWLGAYTQMLIPASIVGVIVFLYGC
ATVDENIPSMEMCDQRYNITMCPLCDKTCSYWKMSSACATARASHLFDNP
ATVFFSVFMALWAATFMEHWKRKQMRLNYRWDLTGFEEEEEAVKDHPRAE
YEARVLEKSWRDRFPAYFTNLVSIIFMIAVTFAIVLGVIIYRISTAAALA
MNPSVRSNIRVTVTATAVIINLVVIILLDEVYGCIARWLTKIEVPKTEKS
FEERLTFKAFLLKFVNSYTPIFYVAFFKGRFVGRPGDYVYIFRSFRMEEC
APGGCLMELCIQLSIIMLGKQLIQNNLFEIGIPKMKKFIRYLKRKQRYEV
DFNLEPFAGLTPEYMEMIIQFGFVTLFVASFPLAPLFALLNNIIEIRLDA
KKFVTELRRPVAIRAKDIGIWYNILRGVGKLAVIINAFVISFTSDFIPRL
VYLYMYSQNGTMHGFVNHTLSSFNVSDFQNGTAPNDPLDLGYEVQICRYK
DYREPPWSEHKYDISKDFWAVLAARLAFVIVFQNLVMFMSDFVDWVIPDI
PKDISQQIHKEKVLMVELFMR
3D structure
PDB7zk3 Inhibition mechanism of the chloride channel TMEM16A by the pore blocker 1PBC.
ChainB
Resolution2.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA B E654 E702 E705 E734 D738 E479 E513 E516 E545 D549
BS02 CA B N650 N651 E654 E734 N475 N476 E479 E545
BS03 JRF B R515 V543 Y598 V599 K603 E633 I636 Q637 R342 V368 Y423 V424 K428 E458 I461 Q462
BS04 CA B D883 I886 D888 D694 I697 D699
Gene Ontology
Molecular Function
GO:0005229 intracellularly calcium-gated chloride channel activity
GO:0005247 voltage-gated chloride channel activity
GO:0005254 chloride channel activity
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0046983 protein dimerization activity
Biological Process
GO:0006821 chloride transport
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0034220 monoatomic ion transmembrane transport
GO:0034605 cellular response to heat
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0042391 regulation of membrane potential
GO:0050965 detection of temperature stimulus involved in sensory perception of pain
GO:0050966 detection of mechanical stimulus involved in sensory perception of pain
GO:0051649 establishment of localization in cell
GO:0060438 trachea development
GO:0070254 mucus secretion
GO:0106091 glial cell projection elongation
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0016324 apical plasma membrane
GO:0034707 chloride channel complex
GO:0042734 presynaptic membrane
GO:0042995 cell projection
GO:0045202 synapse
GO:0098793 presynapse
GO:0098978 glutamatergic synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7zk3, PDBe:7zk3, PDBj:7zk3
PDBsum7zk3
PubMed35589730
UniProtQ8BHY3|ANO1_MOUSE Anoctamin-1 (Gene Name=Ano1)

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