Structure of PDB 7zgu Chain B

Receptor sequence
>7zguB (length=809) Species: 9606 (Homo sapiens) [Search protein sequence]
KDYRKKYRKYVRSRFQCIESVSLNKRYTRLRLIKEHFDPDDEHSEPVHTV
VFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSL
GDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDW
QKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILG
FSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGL
KQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGLCAHLWGLCSLAADGI
WNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQE
FFAAMYYLLERLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERT
SYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQE
EDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHHLTS
SFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWL
GRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLC
NLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCE
KAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDK
GIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLG
NNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPE
LTVVFEPSW
3D structure
PDB7zgu Cryo-EM structure of the NEK7-independent NLRP3 inflammasome
ChainB
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP B R167 A228 G229 G231 K232 T233 I234 Y381 P412 W416 H522 R26 A56 G57 G59 K60 T61 I62 Y209 P240 W244 H345
External links
PDB RCSB:7zgu, PDBe:7zgu, PDBj:7zgu
PDBsum7zgu
PubMed
UniProtQ96P20|NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3 (Gene Name=NLRP3)

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