Structure of PDB 7zez Chain B

Receptor sequence
>7zezB (length=64) Species: 9606 (Homo sapiens) [Search protein sequence]
AKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNL
PESVAYTCVNCTER
3D structure
PDB7zez RNA binding induces an allosteric switch in Cyp33 to repress MLL1-mediated transcription.
ChainB
ResolutionN/A
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.364: [histone H3]-lysine(4) N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B Y1576 D1580 Y1581 M1585 C1588 D1592 W1594 Y1607 L1610 S1611 L1613 V1617 Y13 D17 Y18 M22 C25 D29 W31 Y44 L47 S48 L50 V54
BS02 ZN B C1569 C1572 H1596 C1599 C6 C9 H33 C36
BS03 ZN B C1588 C1591 C1621 C1624 C25 C28 C58 C61
External links
PDB RCSB:7zez, PDBe:7zez, PDBj:7zez
PDBsum7zez
PubMed37075125
UniProtQ03164|KMT2A_HUMAN Histone-lysine N-methyltransferase 2A (Gene Name=KMT2A)

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