Structure of PDB 7zes Chain B

Receptor sequence

>7zesB (length=827) Species: 9606 (Homo sapiens)

PLVVEPSYPDLVINVGEVTLGEENRKKLQKIQRDQEKERVMRAACALLNS
GGGVIRMAKKVEHPVEMGLDLEQSLRELIQSSDLQAFFETKQQGRCFYIF
VKSWSSGPFPEDRSVKPRLCSLSSSLYRRSETSVRSMDSREAFCFLKTKR
KPDPADLIFQKDYLEYGEILPFPESQLVEFKQFSTKHFQEYVKRTIPEYV
PAFANTGGGYLFIGVDDKSREVLGCAKENVDPDSLRRKIEQAIYKLPCVH
FCQPQRPITFTLKIVNVLKRGELYGYACMIRVNPFCCAVFSEAPNSWIVE
DKYVCSLTTEKWVGMMTDVYSKKGLEHKKELQQLLFSVPPGYLRYTPESL
WRDLISEHRGLEELINKQMQPFFRGILIFSRSWAVDLNLQEKPGVICDAL
LIAQNSTPILYTILREQDAEGQDYCTRTAFTLKQKLVNMGGYTGKVCVRA
KVLCLSPVSPMDYPASYSLAGTQHMEALLQSLVIVLLGFRSLLSDQLGCE
VLNLLTAQQYEIFSRSLRKNRELFVHGLPGSGKTIMAMKIMEKIRNVFHC
EAHRILYVCENQPLRNFISDRNICRAETRKTFLRENFEHIQHIVIDEAQN
FRTEDGDWYGKAKSITRRAKGGPGILWIFLDYFQTSHLDCSGLPPLSDQY
PREELTRIVRNADPIAKYLQKEMQVIRSNPSFNIPTGCLEVFPEAEWSQG
VQGTLRIKKYLTVEQIMTCVADTCRRFFDRGYSPKDVAVLVSTAKEVEHY
KYELLKAMRKKRVVQLSDACDMLGDHIVLDSVRRFSGLERSIVFGIHPRT
ADPAILPNVLICLASRAKQHLYIFPWG

3D structure

• PDB: 7zes Mechanistic understanding of human SLFN11.
• Chain: B
• Resolution: 3.1 Å

Enzymatic activity

• Enzyme Commision number: 3.1.-.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	B	N633 Q634 R674 E676 A816 S853 R856 A873	N561 Q562 R602 E604 A744 S781 R784 A801
BS02	ZN	B	H285 C321 C322	H250 C286 C287
BS03	MG	B	E209 E214 K216	E174 E179 K181

Gene Ontology

Molecular Function

• GO:0000049 tRNA binding
• GO:0003677 DNA binding
• GO:0004386 helicase activity
• GO:0004519 endonuclease activity
• GO:0005515 protein binding
• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity

Biological Process

• GO:0002376 immune system process
• GO:0006338 chromatin remodeling
• GO:0006974 DNA damage response
• GO:0008156 negative regulation of DNA replication
• GO:0043111 replication fork arrest
• GO:0051607 defense response to virus
• GO:2000134 negative regulation of G1/S transition of mitotic cell cycle

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005694 chromosome
• GO:0005829 cytosol
• GO:0090734 site of DNA damage

External links

• PDB: RCSB:7zes, PDBe:7zes, PDBj:7zes
• PDBsum: 7zes
• PubMed: 36115853
• UniProt: Q7Z7L1|SLN11_HUMAN Schlafen family member 11 (Gene Name=SLFN11)