Structure of PDB 7zeh Chain B

Receptor sequence
>7zehB (length=275) Species: 9606 (Homo sapiens) [Search protein sequence]
STLMKATVLMRQPGRVQEIVGALRKGGGDRLQVISDFDMTLSRFAYNGKR
CPSSYNILDNSKIISEECRKELTALLHHYYPIEIDPHRTVKEKLPHMVEW
WTKAHNLLCQQKIQKFQIAQVVRESNAMLREGYKTFFNTLYHNNIPLFIF
SAGIGDILEEIIRQMKVFHPNIHIVSNYMDFNEDGFLQGFKGQLIHTYNK
NSSAEGKTNVILLGDSIGDLTMADGVPGVQNILKIGFLNDKVEERRERYM
DSYDIVLEKDETLDVVNGLLQHILC
3D structure
PDB7zeh Substrate-Based Design of Cytosolic Nucleotidase IIIB Inhibitors and Structural Insights into Inhibition Mechanism.
ChainB
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.5: 5'-nucleotidase.
3.1.3.91: 7-methylguanosine nucleotidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IPQ B Y60 D64 W105 W106 A109 Y55 D59 W100 W101 A104
BS02 RBL B E88 T202 E83 T197
BS03 MG B D41 D43 D230 D36 D38 D215
BS04 PO4 B Y60 A157 T202 K205 Y55 A152 T197 K200
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0005515 protein binding
GO:0008253 5'-nucleotidase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0009117 nucleotide metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7zeh, PDBe:7zeh, PDBj:7zeh
PDBsum7zeh
PubMed35631380
UniProtQ969T7|5NT3B_HUMAN 7-methylguanosine phosphate-specific 5'-nucleotidase (Gene Name=NT5C3B)

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