Structure of PDB 7zeg Chain B

Receptor sequence
>7zegB (length=277) Species: 9606 (Homo sapiens) [Search protein sequence]
TLMKATVLMRQPGRVQEIVGALRKGGGDRLQVISDFDMTLSRFAYNGKRC
PSSYNILDNSKIISEECRKELTALLHHYYPIEIDPHRTVKEKLPHMVEWW
TKAHNLLCQQKIQKFQIAQVVRESNAMLREGYKTFFNTLYHNNIPLFIFS
AGIGDILEEIIRQMKVFHPNIHIVSNYMDFNEDGFLQGFKGQLIHTYNKN
SSACENSGKTNVILLGDSIGDLTMADGVPGVQNILKIGFLNDKVEERRER
YMDSYDIVLEKDETLDVVNGLLQHILC
3D structure
PDB7zeg Substrate-Based Design of Cytosolic Nucleotidase IIIB Inhibitors and Structural Insights into Inhibition Mechanism.
ChainB
Resolution1.56 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.5: 5'-nucleotidase.
3.1.3.91: 7-methylguanosine nucleotidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IOO B Y60 E88 W105 W106 A109 S156 A157 K205 Y54 E82 W99 W100 A103 S150 A151 K199
BS02 MG B D41 D43 D230 D35 D37 D217
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0005515 protein binding
GO:0008253 5'-nucleotidase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0009117 nucleotide metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:7zeg, PDBe:7zeg, PDBj:7zeg
PDBsum7zeg
PubMed35631380
UniProtQ969T7|5NT3B_HUMAN 7-methylguanosine phosphate-specific 5'-nucleotidase (Gene Name=NT5C3B)

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