Structure of PDB 7zcz Chain B

Receptor sequence
>7zczB (length=345) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
FYINSKYKIDLDKIMTKMKNKSVINIDDVDDEELLAILYTSKQFEKILKN
NEDSKYLENKVFCSVFLEPSTRTRCSFDAAILKLGSKVLNITDMNSTSFY
KGETVEDAFKILSTYVDGIIYRDPSKKNVDIAVSSSSKPIINAGNGTGEH
PTQSLLDFYTIHNYFPFILDRNINKKLNIAFVGDLKNGRTVHSLSKLLSR
YNVSFNFVSCKSLNIPKDIVNTITYNLKKNNFYSDDSIKYFDNLEEGLED
VHIIYMTRIQKERFTDVDEYNQYKNAFILSNKTLENTRDDTKILHPLPRV
NEIKVEVDSNPKSVYFTQAENGLYVRMALLYLIFSSTSSAWSHPQ
3D structure
PDB7zcz Discovery of Small-Molecule Allosteric Inhibitors of Pf ATC as Antimalarials.
ChainB
Resolution2.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.3.2: aspartate carbamoyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C2B B F136 E140 A145 L149 Y152 F99 E103 A108 L112 Y115
Gene Ontology
Molecular Function
GO:0004070 aspartate carbamoyltransferase activity
GO:0016597 amino acid binding
GO:0016740 transferase activity
GO:0016743 carboxyl- or carbamoyltransferase activity
Biological Process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0006520 amino acid metabolic process
GO:0044205 'de novo' UMP biosynthetic process
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:7zcz, PDBe:7zcz, PDBj:7zcz
PDBsum7zcz
PubMed36195578
UniProtA0A5K1K910

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