Structure of PDB 7z9k Chain B

Receptor sequence
>7z9kB (length=402) Species: 511145 (Escherichia coli str. K-12 substr. MG1655) [Search protein sequence]
GKLADCQERDPALSELYLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVE
KARFDKMLSSQEVATLITALGCGIGRDEYNPDKLRYHSIIIMTDADVDGS
HIRTLLLTFFYRQMPEIVERGHVYIAQPPLYKVKKGKQEQYIKDDEAMDQ
YQISIALDGATLHTNASAPALAGEALEKLVSEYNATQKMINRMERRYPKA
MLKELIYQPTLTEADLSDEQTVTRWVNALVSELNDKEQHGSQWKFDVHTN
AEQNLFEPIVRVRTHGVDTDYPLDHEFITGGEYRRICTLGEKLRGLLEED
AFIERGERRQPVASFEQALDWLVKESRRGLSIQRYKGLGEMNPEQLWETT
MDPESRRMLRVTVKDAIAADQLFTTLMGDAVEPRRAFIEENALKAANIDI
EN
3D structure
PDB7z9k Molecular mechanism of topoisomerase poisoning by the peptide antibiotic albicidin.
ChainB
Resolution3.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B E424 R457 D502 E20 R53 D98
BS02 dna B K447 N452 H505 R788 K43 N48 H101 R384
BS03 IL1 B K447 G743 K43 G339
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003916 DNA topoisomerase activity
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008094 ATP-dependent activity, acting on DNA
GO:0034335 DNA negative supercoiling activity
GO:0046872 metal ion binding
Biological Process
GO:0006261 DNA-templated DNA replication
GO:0006265 DNA topological change
GO:0006351 DNA-templated transcription
GO:0009410 response to xenobiotic stimulus
GO:0046677 response to antibiotic
GO:0051276 chromosome organization
Cellular Component
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0009330 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7z9k, PDBe:7z9k, PDBj:7z9k
PDBsum7z9k
PubMed36741192
UniProtP0AES6|GYRB_ECOLI DNA gyrase subunit B (Gene Name=gyrB)

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